mechanisms of bax/bak activation: is there any light at the end of the tunnel?
نویسندگان
چکیده
in this review we summarize the current knowledge on the mechanisms by which the pore-forming bcl-2 family members bax and bak are activated on the mitochondrial outer membrane (mom) in apoptotic cells. we compare the two major working models and conclude that they are both insufficient to explain reality. instead, we need to identify novel binding partners and posttranslational modifications of bcl-2 family proteins to fully understand their modi operandi in healthy and apoptotic cells.
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عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۲۰۰۹، شماره ۰۷، صفحات ۰-۰
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